维多利亚3308老品牌

维多利亚3308老品牌

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柴 卓


     


     

 

卓(教授,博士生导师)

维多利亚3308老品牌 应用化学系

ORCID: http://orcid.org/0000-0002-9878-8814

教育经历(Education)

1999920037           维多利亚3308老品牌          化学专业      理学学士

2003920087   中国科学院上海有机化学研究所  有机化学专业    理学博士

工作经历(Research experience)

20082009     中国科学院上海有机化学研究所                    助理研究员

20092011     Montana State University (USA)                          博士后

20112012     Université de Rouen et INSA de Rouen (France)             博士后

2012年至今        维多利亚3308老品牌        讲师,副教授,教授(20177月起)

主持项目(Funding)

6. “生物活性分子合成导向的外消旋吖丙啶不对称催化转化研究”,国家自然科学基金面上项目(21971003),直接经费:65万元,2020年1月–2023年12月。

5. “钯(II)-Brønsted acid-亚磷酸酰胺体系在氧化性反应条件下的不对称协同催化应用研究”,国家自然科学基金面上项目(21472001),84万元,2015年1月–2018年12月。

4. “烯烃化合物的不对称串联亲电加成–成环反应研究”,国家自然科学基金青年基金项目(21202001),25万元,2013年1月–2015年12月,已结题。

3. “基于不对称亲电反应的毒扁豆碱类生物碱的合成研究”,安徽省自然科学基金面上项目(1308085MB17),5万元,2013年7月–2015年6月,已结题。

2. “基于不对称亲电反应的吡咯并吲哚啉类生物碱的合成研究”,中科院天然产物重点实验室开放基金项目,3万元,2012年12月–2014年12月,已结题。

1. 维多利亚3308老品牌博士科研启动基金,2万元。

讲授课程(Courses)

1.《精细有机合成》

2. 基础/综合化学实验

研究兴趣(Current Research Projects)

不对称催化,有机合成

课题组成员(Group Members)

在读研究生(Current Members)

博士研究生:暂无

硕士研究生:2017级:漆玲(Ling Qi),秦海林(Hai-Lin Qin),李龙宣(Long-Xuan Li)

2018级:陈中菊(Zhong-Ju Chen),朱国胜(Guo-Sheng Zhu)

2019级:王利亮(Li-Liang Wang),郭明芳(Ming-Fang Guo),杨铭(Ming Yang)

已毕业研究生(Past Members,就业信息更新至201812)

博士研究生:2016级:杨培俊(Pei-Jun Yang,本科毕业于合肥师范学院,安徽工程大学生物与化工学院专任教师)。

硕士研究生:2016级:汪阳(Yang Wang,本科毕业于淮北师范大学),就职于南京梯尔希医药有限公司;刘丙义(Bing-Yi Liu,本科毕业于滁州学院),就职于南京梯尔希医药有限公司。

2015级:张虎(Hu Zhang,王绍武教授共同指导,本科毕业于宿州学院),就职于温州瑞浦能源有限公司

2014级:刘珍(Zhen Liu,杨高升教授共同指导,本科毕业于阜阳师范学院)

2013级:杨培俊(Pei-Jun Yang,杨高升教授共同指导,本科毕业于合肥师范学院)

2012级:朱佑民(You-Min Zhu,王绍武教授共同指导,本科毕业于淮海工学院),就职于北京创腾科技有限公司;陈加男(Jia-Nan Chen,杨高升教授共同指导,本科毕业于阜阳师范学院),就职于南京海纳医药有限公司

2011级:王彪(Biao Wang,杨高升教授共同指导,本科毕业于维多利亚3308老品牌),就职于南京华威医药有限公司。

已发表论文(Publications

2018–2019

23. Yang Wang, Bing-Yi Liu, Gaosheng Yang, Zhuo Chai,* “Synthesis of 2-Aminophosphates via SN2-Type Ring Openings of Aziridines with Organophosphoric Acids”, Org. Lett. 2019, 21, 44754479.

22. Pei-Jun Yang, Ling Qi, Zhen Liu, Gaosheng Yang, Zhuo Chai,* “Lewis Acid-Catalyzed Dynamic Kinetic Asymmetric Transformation of Racemic N-Sulfonylaziridines”, J. Am. Chem. Soc. 2018, 140, 1721117217.

2017

21. Zhuo Chai, Yemei Wang, Mujun Tang, Xiaolong Mu, Jinsong Hou, Gaosheng Yang,* “Chiral rare-earth metal complexes with a tridentate amido-fluorenyl ligand: Syntheses, structures and catalytic performance”, J. Organomet. Chem. 2017,846, 236241. 

20. Deju Hua, Pengfei Yang, Yue Shen, Gaosheng Yang,* Zhuo Chai,* “PCl5-mediated ring-openings of trans-2,3-disubstituted cyclopropane-1,1-diesters: a stereoselective way to trisubstituted vinyl cholorides”, Tetrahedron 2017, 73, 1205–1210.

19. Zhuo Chai, Jiang Chu, Yunyi Qi, Mujun Tang, Jinsong Hou and Gaosheng Yang,* “Half-sandwich chiral rare-earth metal complexes with linked tridentate amido-indenyl ligand: synthesis, characterization, and catalytic properties for intramolecular hydroamination”, RSC Adv., 2017, 7, 1759–1765.

18. Zhuo Chai,* Pei-Jun Yang, Hu Zhang, Shaowu Wang, Gaosheng Yang, “Synthesis of Chiral Vicinal Diamines by Silver(I)-Catalyzed Enantioselective Aminolysis ofN-Tosylaziridines”, Angew. Chem. Int. Ed. 2017, 56, 650654 (highlighted in Synfacts, 2017, 396).

2015–2016

17. Zhuo Chai,* Jia-Nan Chen, Zhen Liu, Xue-Fei Li, Pei-Jun Yang, Ji-Ping Hu, Gaosheng Yang, “[3+2]-Annulations of N-alkyl-3-substituted indoles with quinone monoketals catalysed by Br?nsted acids”, Org. Biomol. Chem. 2016, 14, 10241030.

16. Zhuo Chai,* You-Min Zhu, Pei-Jun Yang, Shaoyin Wang, Shaowu Wang,* Zhen Liu, Gaosheng Yang, “Copper(I)-Catalyzed Kinetic Resolution of N-Sulfonylaziridines with Indoles: Efficient Construction of Pyrroloindolines”, J. Am. Chem. Soc. 2015, 137, 1008810091 (highlighted by X-MOL: http://www.x-mol.com/news/5199).

15. Gaosheng Yang,* Tingting Wang, Jun Chai, Zhuo Chai,* “AlCl3-Catalyzed [3+2] Annulations of cis-2,3-Disubstituted Cyclopropane 1,1-Diesters with Cyclic Ketones: Diastereoselective Construction of Spirotetrahydrofurans”, Eur. J. Org. Chem. 2015, 10401046.

2014

14. Zhuo Chai, Dezhi Hua, Kui Li, Jiang Chu, Gaosheng Yang,* “A novel chiral yttrium complex with a tridentate linked amido-indenyl ligand for intramolecular hydroamination”, Chem. Commun. 2014, 50, 177179.

13. Zhuo Chai,* Biao Wang, Jia-Nan Chen, Gaosheng Yang, “Arylation of Azlactones using Diaryliodonium Bromides and Silver Carbonate: Facile Access to alpha-Tetrasubstituted Amino Acid Derivatives”, Adv. Synth. Catal. 2014,356, 27142718.

12. Zhuo Chai, Dezhi Hua, Kui Li, Jiang Chu, Gaosheng Yang,* “Rare-earth metal complexes with tridentate linked amido-indenyl ligand: Synthesis, characterization, and catalytic properties for intramolecular hydroamination”, J. Organomet. Chem. 2014, 768, 136139.

11. Shaoyin Wang, Xiancui Zhu, Zhuo Chai,* and Shaowu Wang,* “Synthesis of polysubstituted pyrroles via [3+2]-annulation of aziridines and beta-nitroalkenes under aerobic conditions”, Org. Biomol. Chem. 2014, 12, 13511356.

2013

10. Yongxian Sun, Gaosheng Yang,* Zhuo Chai,* Xiaolong Mu, Jun Chai, AlCl3-promoted [3+2] annulation of cis-2,3-disubstituted cyclopropane 1,1-diesters with isothiocyanates: stereoselective synthesis of densely substituted 2-iminodihydrothiophenes”, Org. Biomol. Chem. 2013, 11, 78597868.

9. Yongxian Sun, Gaosheng Yang,* Yue Shen, Hua Zan, Zhuo Chai,* “Stereoselective cyclopropanation of a-bromochalcone with diethyl malonate promoted by K2CO3”, Tetrahedron 2013, 69, 51045111.

8. Gaosheng Yang,* Yongxian Sun, Yue Shen, Zhuo Chai,* Shuangliu Zhou, Jiang Chu, Jun Chai, “cis-2,3-Disubstituted Cyclopropane 1,1-Diesters in [3+2] Annulations with Aldehydes: Highly Diastereoselective Construction of Densely Substituted Tetrahydrofurans”, J. Org. Chem. 2013, 78, 53935400.

7. Zhuo Chai, Jean-Philippe Bouillon, Dominique Cahard,* “Chiral Br?nsted Acid-Catalyzed Diastereo- and Enantioselective Synthesis of CF3-Substituted Aziridines”, Chem. Commun. 2012, 48, 9471–9473.

6. Zhuo Chai, Trevor J. Rainey,* “Pd(II)/Br?nsted Acid Catalyzed Enantioselective Allylic C-H Activation for the Synthesis of Spirocyclic Rings”,J. Am. Chem. Soc. 2012, 134, 3615–3618.

5. Zhuo Chai, Gang Zhao,* “Efficient Organocatalysts Derived From Simple Chiral Acyclic Amino Acids in Asymmetric Synthesis” Catal. Sci. Technol. 2012, 2, 29–41.

4. Zhuo Chai, Hai-Feng Wang, Gang Zhao,* “Ni-Catalyzed Carbocyclization of 1,6-Enynes Mediated by Dialkylzinc Reagents: Me2Zn or Et2Zn Makes a Difference”, Synlett 2009, 17851790.

3. Zhuo Chai, Zheng-Feng Xie, Xin-Yuan Liu, Ji-De Wang*, Gang Zhao*, “Tandem Addition/Cyclization Reaction of Organozinc Reagents to 2-Alkynyl Aldehydes: Highly Efficient Regio- and Enantioselective Synthesis of 1,3-Dihydroisobenzofurans and Tetrasubstituted Furans”, J. Org. Chem. 2008, 73, 29472950 (highlighted in Synfacts, 2008, 712).

2. Zhuo Chai, Xin-Yuan Liu, Jun-Kang Zhang, Gang Zhao*, “Enantioselective Addition of Alkenylzinc Reagents to Aldehydes With Organoboronates as the Alkenyl Source”, Tetrahedron: Asymmetry 2007, 18, 724728.

1. Zhuo Chai, Xin-Yuan Liu, Xiao-Yu Wu, Gang Zhao*, “Synthesis of Modular Thiophene-Oxazoline Ligands and Their Application in the Asymmetric Phenyl Transfer Reaction to Aldehydes”, Tetrahedron: Asymmetry 2006, 17, 24422447.

会议报告

  1. 第十三届江淮有机化学论坛,青年学者报告,“Copper(I)-Catalyzed Enantioselective [3+2] Annulation of Indoles and N-Sulfonylaziridines”,会议时间:20151030日至111日,南京大学(江苏南京)。

  2. 第十四届全国有机合成化学学术研讨会,口头报告,“路易斯酸催化外消旋吖丙啶不对称开环反应研究”,会议时间:20171026日至1029日,淮北师范大学(安徽淮北)。

  3. 第十届全国有机化学学术年会,口头报告,“路易斯酸催化外消旋吖丙啶的立体汇聚式转化反应研究”,会议时间:20171218日至1221日,南方科技大学(广东深圳)。

  4. 中国化学会手性中国2019学术研讨会,口头报告,“外消旋吖丙啶的不对称催化转化反应研究”,会议时间:2019112日至113日,南方科技大学(广东深圳)。

  5. 第十六届全国有机合成化学学术研讨会,邀请报告,“路易斯酸催化外消旋吖丙啶的不对称转化反应研究”,会议时间:201988日至811日,河南大学(河南开封)。

教学研究论文

柴卓,“有机反应立体选择性描述术语 % ee/er% de/dr刍议”,大学化学20173260–62.

柴卓,杨高升,李奎,华德智,“一种稀土配合物催化剂,其制备方法、用途以及应用方法”,中国发明专利, 专利号:ZL 2013 1 0394971.4.

柴卓,朱佑民,王绍武,杨培俊,杨高升,“一种手性六氢吡咯并吲哚类化合物的制备方法”,中国发明专利, 专利号:ZL 2015 1 0262771.2.

柴卓,杨培俊,王绍武,杨高升,“一种手性邻二胺类化合物及其制备方法”,中国发明专利, 专利号:ZL 2016 1 0234895.4.

柴卓,杨培俊,杨高升,“一种手性噁唑烷类化合物及其制备方法”,中国发明专利, 申请号:CN****10761427.7.

Gang Zhao*, Zhuo Chai, Chapter 3: Insoluble Resin-supported Catalysts in Recoverable and Recyclable Catalysts, Benaglia, M. Eds.; John Wiely & Sons: Chichester, 2009, Chapter 3, pp 49-72.

 

 


编辑:柴卓   |   更新日期:2018-12-17   |   点击:19346
 


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