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张继坦课题组

 

张继坦 博士副教授硕士生导师

办公室:花津校区理科实训大楼A楼1115

实验室:花津校区理科实训大楼A楼1127、1126

联系方式:zhangjt@ahnu.edu.cn


教育经历

  • 2012年9月-2016年3月 浙江大学 有机化学博士 (导师:张玉红教授)

  • 2009年9月-2012年7月 维多利亚3308老品牌 理学硕士 (导师:谢美华教授)

  • 2005年9月-2009年7月 维多利亚3308老品牌 理学学士 (导师:谢美华教授)

工作经历

  • 2017年8月-至今 维多利亚3308老品牌  副教授

  • 2016年7月-2017年7月 中山大学 特聘副研究员

经费项目

  • “基于钴催化碳氢键活化的手性氨基酸衍生物的合成反应研究”,中央高校基本科研业务费中山大学青年教师培育项目(31000-31610766),2017年01月-2017年12月,项目负责人。

  • “廉价金属催化的基于碳氢键活化的不对称串联反应”,国家自然科学基金青年项目(21702237),2018年01月-2020年12月,项目负责人。

  • 维多利亚3308老品牌博士科研启动基金,2018年01月-2020年12月,项目负责人。

  • 基于不对称钴催化碳氢键杂原子化的轴手性构建反应研究”,安徽省自然科学基金面上项目(2208085MB23),2022年01月-2024年12月,项目负责人。

  • “基于不对称Catellani型反应的手性氮/磷原子构建及其合成应用研究”,安徽省高校科研编制重大项目(2023AH040028),2023年09月-2026年08月,项目负责人。

研究领域

 

  • 过渡金属催化惰性键断裂

  • 不对称催化

  • 有机合成方法学

课题组

  • 诚挚欢迎每一位对我们课题感兴趣的同学加盟,并欢迎大家随时来参观我们的实验室!

  • 课题组成员

本科生:

创新团队(2016级化学)-周兰、刘楠楠、朱丽

业设计:周兰、朱金瑶、任豪、孙博文、张卫新、田骏鹏

创新实验 居虎(2017级英才班)、丁珂(2017级英才班)、张玥(2018级英才班)、周开元(2018级英才班)、李宇航(2019级英才班)、张军(2019级英才班)、刘冉(2020级化工)王琦(2020级英才班)


硕士生:



  

代表性论文


33) Rh(III)-catalyzed selective C2 C–H acyloxylation of indoles, Chaoying Fang, Li Li, Haitao Yang, Caiyang Kong, Jitan Zhang*, Meihua Xie* and Jiping Wu*, Chem. Commun. 2024, DOI: 10.1039/D3CC05799B.



32) Electrochemical Oxidation of Indoles to Access Tryptanthrins at Room Temperature, Ziyi Guo, Yi Liu, Hang Li, Jiping Wu*, Meihua Xie* and Jitan Zhang*, Adv. Synth. Catal. 2024, DOI: 10.1002/adsc.202301027.


31) Construction of Fully Substituted Cyclobutanes by Tandem Reaction of 1,4-Diyn-3-ols and Anhydrides, Ziyi Guo, Yue Yin, Xiao-Cong Xu, Chang-Qing Liu, Jitan Zhang* and Meihua Xie*, J. Org. Chem. 2023, DOI: 10.1021/acs.joc.3c00530.



30) Palladium-catalyzed Interannular C-H Amination of Biaryl Amines, Jiaping Wu,* Pengpeng Sun, Yuwen Hong, Haitao Yang, Meihua Xie,* Jitan Zhang,* Chem. Commun. 2022, DOI: 10.1039/D2CC05129J.



29) Electrochemical Rhodium-catalyzed C-H Cyclodimerization of Alkynes to Access Diverse Functionalized Naphthalenes: Involvement of RhIV/V and RhI Dual Catalysis, Ziyi Guo, Junjie Zhang, Jitan Zhang,* Meihua Xie,* Org. Lett. 2022, DOI: 10.1021/acs.orglett.2c03122.


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28) Palladium-catalyzed Atroposelective Interannular C-H Arylation of Biaryl Aldehydes with Aryl Iodides Enabled by a Transient Directing Group Strategy, Jitan Zhang,* Jian Fan, Ziyi Guo, Yehe Wu, Jiaping Wu,* Meihua Xie,* Adv. Synth. Catal. 2022, DOI: 10.1002/adsc.202200659.



27) Acid-Promoted C-C Triple Bond Cleavage of Ynones for the Synthesis of Benzo[d]oxazoles/Benzo[d]thiazoles and 1-Arylethan-1-ones, Zi-Yi Guo, Ke-Ru Li, Hang Li, Xu Wang, Ji-Tan Zhang,*  Mei-Hua Xie,* Eur. J. Org. Chem. 2022, DOI: 10.1002/ejoc.202200858.



26) Cu-catalyzed Diarylthiolation of Ynones with Aryl Iodides and Elemental Sulfur: An Access to Tetrasubstituted (Z)-1,2-Bis(arylthio)alkenes and Benzo[b][1,4]dithiines, Yiming Zhao, Xu Wang, Ziyi Guo, Hang Li, Jitan Zhang,* Meihua Xie,* J. Org. Chem. 2022, DOI: 10.1021/acs.joc.2c01575.


25) Pd-Catalyzed Atroposelective C-H Acyloxylation Enabling Access to an Axially Chiral Biaryl Phenol Organocatalyst,  Jitan Zhang,* Jian Fan, Yehe Wu, Ziyi Guo, Jiaping Wu,* Meihua Xie*, Org. Lett. 2022, DOI: 10.1021/acs.orglett.2c01981.


24) Catalytic Ring Expansion of Indole toward Dibenzoazepine Analogues Enabled by Cationic Palladium(II) Complexes,  Jiaping Wu,* Yanfei Liu, Baiyang Qian, Haitao Yang, Lili Lu, Jitan Zhang,* Yongjia Shang*, ACS Catal. 2022, 12, 6216−6226.


23) Temperature controlled di- and monosulfonylation of propargyl alcohols with sodium sulfinates: switchable access to (E)-allyl, vinyldisulfones and propargyl sulfones,  Changqing Liu, Hang Li, Bo Wang, Ziyi Guo, Yu Wang, Jitan Zhang,* and Meihua Xie*, Org. Chem. Front. 2022, DOI: 10.1039/d1qo01906f.


22) K2S2O8-mediated acylarylation of unactivated alkenes via acyl radical addition/C-H annulation cascade of N-allyl-indoles with silver cocatalysis, Jitan Zhang,* Manyi Wu, Hu Ju, Haitao Yang, Ke Ding, Li Zhu, Jiaping Wu,* and Meihua Xie*, Org. Chem. Front. 2022, DOI: 10.1039/d1qo01069g.


21) Pd(II)-catalyzed enantioconvergent twofold C-H annulation to access atropisomeric aldehydes: A platform for diversity-orientedsynthesis, Jitan Zhang,* Qiaoqiao Xu, Jian Fan, Lan Zhou, Nannan Liu, Li Zhu, Jiaping Wu,* and Meihua Xie*, Org. Chem. Front. 2021, DOI: 10.1039/D1QO00183C.

20) Construction of 3-Sulfonyl Naphthalenes via Tandem Reaction of 1,4-Diyn-3-yl Esters with Sodium Sulfinates, Ziyi Guo, Yiming Zhao, Yu Wang,  Meihua Xie* and Jitan Zhang*, J. Org. Chem. 2021, DOI: 10.1021/acs.joc.1c00038.

 

                                           

19) Access to C2 C-H olefination, alkylation and deuteration of indoles by rhodium(III) catalysis: An entry for diverse synthesis, Jiaping Wu,* Baiyang Qian, Haitao Yang, Lili Lu, Yongjia Shang,* Jitan Zhang, Org. Chem. Front. 2021, DOI: 10.1039/D1QO00133G.

 

18) Expeditious synthesis of phenanthridines through a Pd/MnO2-mediated C–H arylation/oxidative annulation cascade from aldehydes, aryl iodides and amino acids, Jian Fan, Li Li, Jitan Zhang*, Meihua Xie*, Chem. Commun. 2020, DOI: 10.1039/d0cc00300j.

 

 


17) Acid-Controlled Access to β‑Sulfenyl Ketones and α,β-Disulfonyl Ketones by Pummerer Reaction of β‑Keto Sulfones and Sulfoxides, Jian Fan, Yiming Zhao, Jitan Zhang, Meihua Xie*, Yuzhong Zhang*, J. Org. Chem. 2020, 85, 691.

 

 


16) Construction of N−C Axial Chirality through Atroposelective C−H Olefination of N‑Arylindoles by Palladium/Amino Acid Cooperative Catalysis, Jitan Zhang,* Qiaoqiao Xu, Jiaping Wu, Jian Fan, Meihua Xie*, Org. Lett. 2019, 21, 6361. (Highlighted by Synfacts, 2019, 15, 1156)

 

 

15) Metal-free cascade rearrangement/radical addition/oxidative C–H annulation of propargyl alcohols with sodium sulfinates: access to 2-sulfenylindenones, Changqing Liu, Bo Wang, Ziyi Guo, Jitan Zhang, Meihua Xie*, Org. Chem. Front. 2019, 6, 2796.


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14) Selective C–H acylation of indoles with a-oxocarboxylic acids at the C4 position by palladium catalysis, Jitan Zhang,* Manyi Wu, Jian Fan, Qiaoqiao Xu, Meihua Xie,* Chem. Commun. 2019, DOI: 10.1039/c9cc03893k.

 



13) NH4I-promoted N-acylation of amines via the transamidation of DMF and DMA under metal-free conditions, Jiahui Chen, Jin Jia, Ziyi Guo, Jitan Zhang,* Meihua Xie*, Tetrahedron Lett. 2019, 60, 1426.


12) Synthesis of 2-Acetyl Trisubstituted Furans via Copper-Mediated Deacylation Cleavage of Unstrained C(sp3)-(sp2) Bonds, Jian Fan, Shengke Wang, Jiahui Chen, Manyi Wu, Jitan Zhang,* Meihua Xie*, Org. Chem. Front. 2019, 6, 437.



11) Metal-Free Functionalized Tetrasubstituted Alkenes by Three-Component Reaction of Alkynes, Iodine, and Sodium Sulfinates, Jitan Zhang,* Zhenda Liang, Jun Wang, Ziyi Guo, Changqing Liu, Meihua Xie,* ACS Omega 2018, 3, 18002.



10) Enantioselective Synthesis of C–N Axially ChiralN-Aryloxindoles by Asymmetric Rhodium-Catalyzed Dual C-H Activation, Honghe Li,# Xiaoqiang Yan,Jitan Zhang, Weicong Guo, Jijun Jiang, and Jun Wang,* Angew. Chem. Int. Ed.2019, DOI: 10.1002/anie.201901619.


9) Copper(II)/Silver(I)-Catalyzed Sequential Alkynylation and Annulation of Aliphatic Amides with Alkynyl Carboxylic Acids: Efficient Synthesis of Pyrrolidones, Jitan Zhang, Danyang Li, Hui Chen, Binjie Wang, Zhanxiang Liu, Yuhong Zhang,* Adv. Synth. & Catal. 2016, 358, 792.


8) An Approach to Five-Membered Lactams from Aliphatic Amides and Terminal Acetylenes by Nickel Catalysis, Cong Lin, Jitan Zhang, Zhengkai Chen, Yue Liu, Zhanxiang Liu, Yuhong Zhang,* Adv. Synth. & Catal. 2016, 358, 1778.


7) Cobalt-Catalyzed Cyclization of Aliphatic Amides and Terminal Alkynes with Silver Cocatalyst, Jitan Zhang, Hui Chen, Cong Lin, Zhanxiang Liu, Chen Wang, Yuhong Zhang,* J. Am. Chem. Soc. 2015, 137, 12990.


6) Copper-Mediated Aryloxylation and Vinyloxylation of β-(sp3)-H Bond of Propionamides with Organosilanes, Jitan Zhang, Hui Chen, Binjie Wang, Zhanxiang Liu, Yuhong Zhang,* Org. Lett. 2015,17, 2768.


5) Rhodium(III)-Catalyzed One-Pot Access to Isoquinolines and Heterocycle-Fused Pyridines in Aqueous Medium through C-H Cleavage, Jitan Zhang, Hongsheng Qian, Zhanxiang Liu, Chunhua Xiong, Yuhong Zhang*, Eur. J. Org. Chem. 20142014, 8110.


4) Regio-and stereoselective synthesis of highly functionalized vinyl ethers via coiodination of acetylenic ketones, Meihu Xie,* Jitan Zhang, Peng Ning, Zhannan Zhang, Xing Liu, Linbo Wang, Tetrahedron Lett. 2014, 55, 1065.


3) Pd(II)-catalyzed C(sp2)-H carbonylation of biaryl-2-amine: synthesis of phenanthridinones, Zunjun Liang, Jitan Zhan, Zhanxiang Liu, Kai Wang, Yuhong Zhang,* Tetrahedron 2013, 69, 6519.


2) Transition metal-catalyzed C-H bond functionalizations by the use of diverse directing groups, Zhengkai Chen, Binjie Wang, Jitan Zhang, Wenlong Yu, Zhanxiang Liu, Yuhong Zhang,* Org. Chem. Front. (Review), 20152, 1107.


1) Synthesis of Benzyl Esters via Functionalization of Multiple C-H Bonds by Palladium Catalysis, Danyang Li, Ming Yu, Jitan Zhang, Zhanxiang Liu, Yuhong Zhang,* Org. Lett. 2015, 17, 5300.




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