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王见


 

王 见  副教授,博士生导师

Email: wang_jian989@163.com




教育经历

  • 2011-2016 中科院广州生物医药与健康研究院 博士 导师:朱强研究员

  • 2007-2011 安徽大学 学士


工作经历

  • 2017-至今 维多利亚3308老品牌维多利亚3308老品牌

  • 2018-2019  Oregon Health & Science University, 博士后,合作导师Prof. Dr. Xiangshu Xiao

     

主持项目

  • 国家自然科学基金面上项目(22171006),主持

  • 安徽省高等学校优秀青年教师培育项目(重点),主持

  • 国家自然科学基金青年项目(21702003)主持

  • 安徽省自然科学基金青年项目(1808085QB31)主持


研究方向

  • 小分子插入反应

  • 不对称催化


成员

  • 现成员:博士生:赵海霞,蒲玥

         硕士生:曾苏云,倪博涵,唐凯杰,张菁萱

  • 已毕业:蔡盼圆(安徽医科大学),刘源(中山大学攻读博士),钟令(中国药科大学攻读博士),

         丁淑敏,李连杰(同济大学攻读博士),陈陈(兰州化物所攻读博士),柴敏学,李丹,

         江雨辰,翁同庆


发表论文


(33) CG-SLENP: A Chemical Genetics Strategy To Selectively Label Existing Proteins and Newly Synthesized Proteins. Jian Wang, Bo Chao, Jake Piesner, Felice Kelly, Stefanie Kaech Petrie, Xiangshu Xiao, and Bingbing X. Li.* JACS Au, 2024Accepted.

DOI: doi.org/10.1021/jacsau.4c00461


(32) Electrophile-Controlled Regiodivergent Palladium-Catalyzed Imidoylative Spirocyclization of Cyclic Alkenes. Shumin Ding, Yue Pu, Jiao Lin, Haixia Zhao, Qiang Tang, Jian Wang.* Org. Lett, 2024, 26, 1908.

DOI: doi.org/10.1021/acs.orglett.4c00181


(31) Three-Component Synthesis of Multiple Functionalized Allenes via Copper/Photoredox Dual Catalyzed 1,4-Alkylcyanation of 1,3-Enynes. Yue Pu, Shumin Ding, Haixia Zhao, Qiaoli Xue, Heng Zhang, Xiaotian Xie, Yongjia Shang, and Jian Wang.* Org. Lett, 2024, 26, 1834.

DOI: doi.org/10.1021/acs.orglett.3c04360


(30) Palladium-catalysed aryl/monofluoroalkylation of allenamides: access to fluoroalkyl indoles and isoquinolones. Qiaoli Xue,‡ Yue Pu,‡ Haixia Zhao, Xiaotian Xie, Heng Zhang, Jian Wang,* Liqin Yan* and Yongjia Shang.* Chem. Commun., 2024, 60, 3794-3797.

DOI:doi.org/10.1039/D4CC00657G


(29) Discovery of LHF418 as a new potent SOS1 PROTAC degrader. Huifan Li, Minxue Chai, Yihan Chen, Fengtao Zhou, Xiaomei Ren, Jian Xu, Jian Wang,* Zhen Wang,* Weixue Huang.* Bioorganic & Medicinal Chemistry, 2024, 103, 117661.

DOI: doi.org/10.1016/j.bmc.2024.117661



(28) Stereoselective Three-Component Construction of Conjugated 1,3-Dienes via Palladium-Catalyzed Alkene/Allene/Carbenoid Insertion Cascade. Haixia Zhao, Yuchen Jiang, Tongqing Weng, Yongjia Shang,* and Jian Wang.* Adv. Synth. & Catal. 2023, 365, 463.

DOI: https://doi.org/10.1002/adsc.202201255


(27) Stereoselective Construction of Unsymmetrically Linked Heterocycles via Palladium-Catalyzed Alkyne Insertion/Cycloimidoylation Cascade.  Haixia Zhao, Shumin Ding, Dan Li, Minxue Chai, Lixiong Dai*, Jing Li*, Yuchen Jiang, Tongqing Weng, and Jian Wang.* J. Org. Chem. 2023, 88, 1613.

DOI: https://doi.org/10.1021/acs.joc.2c02660


(26) Palladium-catalyzed dearomative 1,4-arylmethylenation of naphthalenes. Enshen Zhang, Chen Chen, Xueling Wang, Jian Wang,* and Yongjia Shang.* Org. Chem. Front. 2022, 9, 2600.

DOI: https://doi.org/10.1039/D2QO00266C


(25) Silver-promoted dearomative [3+4] cycloaddition of anthranils with α-isocyanoacetates: access to benzodiazepines. Rui Shao,# Haixia Zhao,# Shumin Ding, Lianjie Li, Chen Chen, Jian Wang* and Yongjia Shang.* Chem. Commun, 2022, 58, 4771-4774.

DOI:https://doi.org/10.1039/D2CC00807F


(24) Palladium-catalysed alkenyl and carbonylative C-C bond activation of cyclobutanones. Chen Chen, Haixia Zhao, Yue Pu, Lulu Tang, Jian Wang* and Yongjia Shang.Chem. Commun, 2021, 57, 12944-12947.

DOI:https://doi.org/10.1039/D1CC05286A


(23) Palladium-catalysed imidoylative spirocyclization of 3-(2-isocyanoethyl)indoles. Shi Tang,# Shumin Ding,# Dan Li, Lianjie Li, Haixia Zhao, Minxue Chai, and Jian Wang.* Chem. Commun, 2021, 57, 10576-10579.

DOI: https://doi.org/10.1039/D1CC03240B


(22) Enantioselective Construction of 1H-Isoindoles Containing Tri- and Difluoromethylated Quaternary Stereogenic Centers via Palladium-Catalyzed C−H Bond Imidoylation. Jian Wang,* Lianjie Li, Minxue Chai, Shumin Ding, Jing Li, Yongjia Shang,* Haixia Zhao, Dan Li, and Qiang Zhu.* ACS Catal. 2021, 11, 12367–12374.

DOI: https://doi.org/10.1021/acscatal.1c03682


(21) Advances in Palladium-Catalysed Imidoylative Cyclization of Functionalized Isocyanides for the Construction of N-Hetrocycles. Jian Wang,* Dan Li, Jing Li, and Qaing Zhu.* Org. Biomol. Chem., 2021, 19, 6730-6745(Invited Review)

DOI: doi.org/10.1039/D1OB00864A


(20) Palladium-Catalyzed Divergent Imidoylative Cyclization of Multi-Functionalized Isocyanides: Tunable Access to Oxazol-5(4H)-ones and Cyclic Ketoimines. Jian Wang,* Ling Zhong, Shi Tang, Yuan Liu, Shumin Ding, Lianjie Li, Haixia Zhao, Chen Chen,Yongjia Shang*. J. Org. Chem. 2020, 85, 7297.

DOI: org/10.1021/acs.joc.0c00672


(19) Palladium-catalysed dearomative aryl/cycloimidoylation of indoles. Jian Wang,* Yuan Liu, Zhuang Xiong, Ling Zhong, Shumin Ding, Lianjie Li, Haixia Zhao, Chen Chen, Yongjia Shang*. Chem. Commun, 2020, 56, 3249. (HOT Article) 

DOI: 10.1039/D0CC00402B

(Outside Front Cover


(18) Rh (III)-Catalyzed Relay Double Carbenoid Insertion and Diannulation of Sulfoximine Benzamides with α‑Diazo Carbonyl Compounds: Access to Furo[2,3-c]isochromenes. Chen Yang, Chen Chen, Shunfan Li, Xinwei He, Youpeng Zuo, Wangcheng Hu, Tongtong Zhou, Jian Wang,* and Yongjia Shang*. Org. Lett, 2020, 22, 2506. (Cover Article

DOI: 10.1021/acs.orglett.9b04659

 

(17) Tuneable Access to Isoquinolines via a Transition-Metal-Free C(sp3)-C(sp3) Bond Cleavage Rearrangement Reaction. Jian Wang,* Panyuan Cai, Yimiao He, Yuan Liu, Ling Zhong, Shumin Ding, Yongjia Shang*. Org. Chem. Front. 2019, 6, 2430.


(16) Access to 1-Amino-3,4-dihydroisoquinolines via Palladium-Catalyzed C-H Bond Aminoimidoylation Reaction from Functionalized Isocyanides. Zhuang Xiong,* Panyuan Cai, Yingshuang Mei, and Jian Wang*. RSC. Adv, 2019, 9, 42072.


(15) Rhodium (II) Acetate-Catalysed Cyclization of Pyrazol-5-amine and 1,3-Diketone-2-diazo Compounds using N,N-Dimethylformamide as a Carbon-Hydrogen Source: Access to Pyrazolo[3,4-b]pyridines.  Yi Ning, Xinwei He, Youpeng Zuo, Panyuan Cai, Mengqing Xie, Jian Wang,* Yongjia Shang*, Adv. Synth. & Catal. 2019, 361, 3518.


(14) Ru(II)/Ir(III)-Catalyzed C–H Bond Activation/Annulation of Cyclic Amides with 1,3-Diketone-2-diazo Compounds: Facile Access to 8H-Isoquinolino[1,2-b]quinazolin-8-ones and Phthalazino[2,3-a]cinnoline-8,13-diones. Panyuan Cai, Enshen Zhang, Yinsong Wu, Taibei Fang, Qianqian Li, Chen Yang, Jian Wang,* Yongjia Shang* ACS Omega, 2018, 3, 14575.


(13) I2-Catalyzed intramolecular dehydrogenative aminooxygenation of alkynes to acylated imidazo[1,2-a]pyridines and indolizines. Yimiao He,* Wenqing, Yin, Jian Wang, Jianrong Huang, Xinru Pang, Chuanfang Gan, Fang Yang, Chusheng Huang.* Org. Chem. Front., 2018, 5, 1772.


(12) I2-catalyzed intramolecular oxidative amination of C(sp3)-H bond: efficient access to 3-acylimidazo[1,2-a]pyridines under neat condition. Lilan Huang, Wenqing Yin, Jian Wang, Chunfang Gan, Yanmin Huang, Chusheng Huang,* Yimiao He.* RSC Adv., 2019, 9, 2381.


Before AHNU

(11) Palladium-Catalyzed Enantioselective C(sp2)-H Imidoylation by Desymmetrization. Jian Wang, De-Wei Gao, Jinbo Huang, Shi Tang, Zhuang Xiong, Huaanzi Hu, Shu-Li You,* Qiang Zhu.* ACS Catal. 2017, 7, 3832.


(10) Intramolecular Imidoylative Heck Reaction: Synthesis of Cyclic Ketoimines from Functionalized Isocyanide. Jian Wang, Shi Tang, Qiang Zhu.* Org. Lett. 2016, 18, 3074.


(9) Copper-Promoted Cycloaddition of α-Methylenyl Isocyanides with Benzothiazoles: Tunable Access to Benzo[d]imidazothiazoles. Jian Wang, Jing Li, Qiang Zhu.* Org. Lett. 2015, 17, 5336.


(8) Palladium-Catalyzed Imidoylative Cyclization of α-Isocyanoacetamides: Efficient Access to C2-Diversified Oxazoles. Jian Wang, Shuang Luo, Jinbo Huang, Tingting Mao, Qing Zhu.* Chem. Eur. J. 2014, 20, 11220.


(7) A Room-Temperature Synthesis of 2, 2’-Bisoxazoles through Palladium-Catalyzed Oxidative Coupling of α-Isocyanoacetamides. Jian Wang, Shuang Luo, Jing Li, Qiang Zhu.* Org. Chem. Front. 2014, 1, 1285.


(6) Transition-Metal-Free Amidoalkylation of Benzothiazoles and Amidoalkylarylation of Activated Alkenes with N, N-Dialkylamides. Jian Wang, Jing Li, Jinbo Huang, Qiang Zhu.* J. Org. Chem. 2016, 81, 3017.


(5) Palladium-Catalyzed Imidoylative Cyclization of Tryptophan-Derived Isocyanides: Access to Carbolines. Shi Tang, Jian Wang, Zhaung Xiong, Zeqiang Xie, Dengke Li, Jinbo Huang, Qiang Zhu.* Org. Lett. 2017, 19, 5577.


(4) Palladium-catalyzed C(sp2)–H aminoimidoylation of isocyano-containing arenes: synthesis of amino substituted N-heterocycles. Zhuang Xiong, Jian Wang, Shuang Luo, Qiang Zhu.* Org. Chem. Front., 2017, 4, 1768.


(3) Copper-Catalyzed C(sp2)-H Amidation with Azides as Amino Sources. Jiangling Peng, Zeqiang Xie, Ming Chen, Jian Wang, Qiang Zhu.* Org. Lett. 2014, 16, 4702.


(2) Synthesis of 1H‐Indole‐3‐carboxamidines through a Palladium‐Catalyzed Three‐Component Reaction Involving Isocyanide Insertion as a Key Step. Ziwei Hu, Jian Wang, Dongdong Liang, Qiang Zhu.* Adv. Synth. & Catal. 2013, 16, 3290.


(1) Palladium-Catalyzed Intramolecular C(sp2)-H Imidoylation for the Synthesis of Six-Membered N-Heterocycles. Jing Li, Yimiao He, Shuang Luo, Jian Lei, Jian Wang, Zeqiang Xie, Qiang Zhu.* J. Org. Chem., 2015, 80, 2223.

 



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